Publications:

Basma, H., Norrby-Teglund, A., McGeer, A., Low, D. E., El-Ahmedy, O., Dale, J. B., Schwartz, B., and Kotb, M. Opsonic antibodies to the surface M protein of group A streptococci in pooled normal immunoglobulins (IVIG): potential impact on the clinical efficacy of IVIG therapy for severe invasive group A streptococcal infections. Infect.Immun. 66[5], 2279-2283. 1998.

Betschel, S. D., Borgia, S. M., Barg, N. L., Low, D. E., and De Azavedo, J. C. Reduced virulence of group A streptococcal Tn916 mutants that do not produce streptolysin S. Infect.Immun. 66[4], 1671-1679. 1998.

Gubba, S., Low, D. E., and Musser, J. M. Expression and characterization of group A Streptococcus extracellular cysteine protease recombinant mutant proteins and documentation of seroconversion during human invasive disease episodes. Infect.Immun. 66[2], 765-770. 1998.

Louie, L., Simor, A. E., Louie, M., McGeer, A., and Low, D. E. Diagnosis of group A streptococcal necrotizing fasciitis by using PCR to amplify the streptococcal pyrogenic exotoxin B gene. J.Clin.Microbiol. 36[6], 1769-1771. 1998.

McIsaac, W. J., White, D., Tannenbaum, D., and Low, D. E. A clinical score to reduce unnecessary antibiotic use in patients with sore throat. CMAJ. 158[1], 75-83. 1-13-1998.

Norrby-Teglund, A., Basma, H., Andersson, J., McGeer, A., Low, D. E., and Kotb, M. Varying titers of neutralizing antibodies to streptococcal superantigens in different preparations of normal polyspecific immunoglobulin G: implications for therapeutic efficacy [see comments]. Clin.Infect.Dis. 26[3], 631-638. 1998.

Betschel, S. D., Guru, V., Miller, C. W., Mathews, K. A., Prescott, J. F., and Low, D. E. Canine toxic-shock syndrome. An emerging disease? Adv.Exp.Med.Biol. 418, 189-192. 1997.

Borgia, S. M., Betschel, S., Low, D. E., and De Azavedo, J. C. Cloning of a chromosomal region responsible for streptolysin S production in Streptococcus pyogenes. Adv.Exp.Med.Biol. 418, 733-736. 1997.

Kaul, R., McGeer, A., Low, D. E., Green, K., Schwartz, B., Oreopoulos, D. G., Ontario Group A Streptococcal Study, and Simor, A. E. Population-based surveillance for group A streptococcal necrotizing fasciitis: Clinical features, prognostic indicators, and microbiologic analysis of seventy-seven cases. Am.J.Med. 103[1], 18-24. 1997.

Newton, D., Norrby-Teglund, A., McGeer, A., Low, D. E., Schlievert, P. M., and Kotb, M. Novel superantigens from streptococcal toxic shock syndrome Streptococcus pyogenes isolates. Adv.Exp.Med.Biol. 418, 525-529. 1997.

Norrby-Teglund, A., Low, D. E., McGeer, A., and Kotb, M. Superantigenic activity produced by group A streptococcal isolates is neutralized by plasma from IVIG-treated streptococcal toxic shock syndrome patients. Adv.Exp.Med.Biol. 418, 563-566. 1997.

Miller, C. W., Prescott, J. F., Mathews, K. A., Betschel, S. D., Yager, J. A., Guru, V., DeWinter, L., and Low, D. E. Streptococcal toxic shock syndrome in dogs. J.Am.Vet.Med.Assoc. 209[8], 1421-1426. 10-15-1996.

Davies, H. D., McGeer, A., Schwartz, B., Green, K., Cann, D., Simor, A. E., Low, D. E., and The Ontario Group A Streptococcal Study Group. Invasive group A streptococcal infections in Ontario, Canada. Ontario Group A Streptococcal Study Group. N.Engl.J.Med. 335[8], 547-554. 8-22-1996.

Norrby-Teglund, A., Kaul, R., Low, D. E., McGeer, A., Andersson, J., Andersson, U., and Kotb, M. Evidence for the presence of streptococcal-superantigen-neutralizing antibodies in normal polyspecific immunoglobulin G. Infect.Immun. 64[12], 5395-5398. 1996.

Norrby-Teglund, A., Kaul, R., Low, D. E., McGeer, A., Newton, D. W., Andersson, J., Andersson, U., and Kotb, M. Plasma from patients with severe invasive group A streptococcal infections treated with normal polyspecific IgG inhibits streptococcal superantigen-induced T cell proliferation and cytokine production. J.Immunol. 156[8], 3057-3064. 4-15-1996.

Ramage, L., Green, K., Prskir, D., Simor, A. E. An outbreak of fatal nosocomial infections due to group A streptococcus on a medical ward. Infec.Control Hosp. Epidemiol. 17[7],429-431. 1996.

Prescott, J. F., Mathews, K., Gyles, C. L., Matsumiya, L., Miller, C., Rinkhardt, N., Yager, J. A., Hylands, R. H., and Low, D. E. Canine streptococcal toxic shock syndrome in Ontario: An emerging disease? Can.Vet.J. 36[8], 486-487. 1995.

Watanabe-Ohnishi, R., Low, D. E., McGeer, A., Stevens, D. L., Schlievert, P. M., Newton, D., Schwartz, B., Kreiswirth, B., Ostach, C., Ontario Streptococcal Study Project, and Kotb, M. Selective depletion of V beta-bearing T cells in patients with severe invasive group A streptococcal infections and streptococcal toxic shock syndrome. J.Infect.Dis. 171[1], 74-84. 1995.

Davies, H. D., Low, D. E., Schwartz, B., Scriver, S., Fletcher, A., O'Rourke, K., Ipp, M., Goldbach, M., Lloyd, D., and Saunders, N. R., The Ontario GAS Study Group. Evaluation of short-course therapy with cefixime or rifampin for eradication of pharyngeally carried group A streptococci. Clin.Infect.Dis. 21[5], 1294-1299. 1995.

Ofner, M., Carlson, J., McGeer, A., and Low, D. Severe invasive group A streptococcal infections in Ontario, 1990-1994 [published erratum appears in Can Commun Dis Rep 1994 Jul 30;20(14):120]. Can.Commun.Dis.Rep. 20[11], 92-93. 6-15-1994.

Jamieson, F. B., Green, K., Low, D. E., Simor, A. E., Goldman, C., Ng, J., and McGeer, A. A cluster of surgical wound infections due to unrelated strains of group A streptococci. Infect.Control.Hosp.Epidemiol. 14[5], 265-267. 1993.

Demers, B., Low, D.E., Simor, A. E., Vellend, H., Jamieson, F., Walmsley, S., Green, K., Krishnan, C., The Ontario Streptoccoccal Study Group. Severe group A streptococcal disease – Southern Ontario. Can.Dis.Wkly.Rep. 17(35),192-4. 1991.