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January 2001
Presented by: Dr. A. Sarabia



An 81 year old man was admitted to hospital because of pain and subcutaneous emphysema (gas) in the right upper extremity. His previous history was unremarkable except for microcytic anemia, which had been recently investigated with upper endoscopy, revealing nothing of significance.

Within 10 hours of admission, the patient had developed subcutaneous gas involving most of his right side and a visible bruise over the right arm, surrounded by large bullae. He was taken to the operating room, where debridement of the necrotic muscle tissues involving right upper arm, shoulder and chest took place. During the procedure, he developed significant hypotension, which responded to medication and intravenous saline and albumin infusion. Postoperatively, however, he remained unresponsive and hypotensive. Disseminated intravascular coagulation developed. Within 30 hours of presentation to hospital, the patient died.


  1. What organisms are associated with rapidly progressive gas-forming infections?
  2. What term is used to describe the above infectious process?
  3. During the operative procedure, tissue is sent to the laboratory for stat gram stain. This reveals only few neutrophils, and gram positive as well as negative bacilli, with no spores. What is the likely etiologic agent of infection?
  4. Why is there a paucity of neutrophils?
  5. What underlying medical conditions are associated with an infection as described above?
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