Services :: Molecular Mechanisms

With a proven record in genetics and molecular research, the ToCARE group has studied the mechanisms of drug resistance at the molecular level. Their published research has determined genetic linkages, characterized resistance operons and studied recombination events as they relate to drug resistance and efficacy.

Related Research Articles

• Bast D.J. Athamna A., Duncan C., de Azavedo J.C.S., Low D.E., Rahav G. , Farrell D. and Rubenstein E. Type II topoisomerase mutations in Bacillus anthracis associated with high-level quinolone resistance. J. Antimicrob.Chemother. 54: 90-94. (2004)
• Fuller J.D., Camus A.C., Duncan C.L., Nizet V., Bast D.J., Thune R.L., Low D.E., de Azavedo J. (2002). Identification of a Streptolysin S-Associated Gene cluster and its Role in the Pathogenesis of S.iniae Disease. Infect. Immun. 70: 5730-5739. (2002)

• Bast DJ. de Azavedo JC. Tam TY. Kilburn L. Duncan C. Mandell LA. Davidson RJ. Low DE. Interspecies recombination contributes minimally to fluoroquinolone resistance in Streptococcus pneumoniae. Antimicrob Agents Chemother. 45(9):2631-2634. (2001)

• Fuller JD. Bast DJ. Nizet V. Low DE. de Azavedo JC. Streptococcus iniae virulence is associated with a distinct genetic profile. Infect Immun. 69(4):1994-2000. (2001)

• Rice K. Peralta R. Bast D. de Azavedo J. McGavin MJ. Description of staphylococcus serine protease (ssp) operon in Staphylococcus aureus and nonpolar inactivation of sspA-encoded serine protease. Infect Immun. 69(1):159-169. (2001)

• Nizet, V., Beall, B., Bast, DJ., Datta, V., Kilburn, L., Low, DE., and de Azavedo, JCS. Genetic Locus for Streptolysin S production by Group A Streptococcus. Infect Immun. 68:4245-4254. (2000)

• de Azavedo, JCS., Yeung, RH., Bast, DJ., Duncan, CL., Borgia, SB., and Low, DE. Prevalence and mechanisms of macrolide resistance in clinical isolates of Group A Streptococci from Ontario, Canada. Antimicrob Agents Chemother. 43:2144-2147. (1999)