Services :: Animal Models

Our research group has developed new research models that improve the degree of standardization while conducting drug efficacy studies. We have established a murine model of pneumococcal pneumonia that is being used to examine efficacy of new compounds and selection for resistance in vivo.

Related Research Articles

• Bast DJ, Yue M, Chen X, Bell D, Dresser L, Saskin R, Mandell LA, Low DE, de Azavedo JC. Novel murine model of pneumococcal pneumonia: use of temperature as a measure of disease severity to compare the efficacies of moxifloxacin and levofloxacin. Antimicrob Agents Chemother. 48(9):3343-3348. (2004)

• Fuller JD, Camus AC, Duncan CL, Nizet V, Bast DJ, Thune RL, Low DE, De Azavedo JC. Identification of a streptolysin S-associated gene cluster and its role in the pathogenesis of Streptococcus iniae disease. Infect Immun. 70(10):5730-5739. (2002)

• Fuller JD. Bast DJ. Nizet V. Low DE. de Azavedo JC. Streptococcus iniae virulence is associated with a distinct genetic profile. Infect Immun. 69(4):1994-2000. (2001)

• Sloane R, de Azavedo JC, Arbuthnott JP, Hartigan PJ, Kreiswirth B, Novick R, Foster TJ. A toxic shock syndrome toxin mutant of Staphylococcus aureus isolated by allelic replacement lacks virulence in a rabbit uterine model. FEMS Microbiol Lett. 62(2-3). (1991)

   

   

  
  

  
  
  

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